建立了皮革样品中五氯酚的串联质谱分析方法，以m／z266为母离子，碰撞电压为0．8V，以子离子m／z230为定量离子，外标法定量。线性范围为0．1－10．0mg／L，检出限为0．005mg／kg，回收率为85．4％－102．5％，相对标准偏差为2．55％－3.55％。方法具有快速、准确的特点。 A tandem mass spectrometry method was established for the determination of pentachlorophenol in leather samples. The m / z 266 ion was used as the precursor ion and the collision voltage was 0.8 V. The ion m / z 230 was used as the quantitative ion and the external standard method was used for the quantitative determination. The linear range was 0.1-10.0 mg / L, the detection limit was 0.005 mg / kg, the recovery was 85.4% -102.5% and the relative standard deviation was 2.55% -3.55%. The method is fast and accurate.