目的分析重症肺炎并脓毒血症患儿血浆C反应蛋白(CRP)水平和血小板计数(PLT)变化及其临床意义。方法选取2013年1月—2015年10月宝鸡市妇幼保健院儿科重症监护室(ICU)收治的重症肺炎患儿89例,根据脓毒血症发生情况分为对照组(未并发脓毒血症,n=34)和观察组(并发脓毒血症,n=55)。比较两组患儿治疗前后血浆CRP水平、PLT及小儿危重症评分(PCIS)。结果治疗前两组患儿血浆CRP水平比较,差异无统计学意义(P>0.05);治疗后观察组患儿血浆CRP水平高于对照组(P<0.05)。治疗后对照组患儿血浆CRP水平低于治疗前(P<0.05),而观察组患儿血浆CRP水平与治疗前比较,差异无统计学意义(P>0.05)。治疗前观察组患儿PLT高于对照组(P<0.05);治疗后两组患儿PLT比较,差异无统计学意义(P>0.05)。治疗后两组患儿PLT均低于治疗前(P<0.05)。治疗前、后两组患儿病情严重程度比较,差异均无统计学意义(P>0.05);治疗后对照组患儿病情严重程度轻于治疗前(P<0.05),而观察组患儿病情严重程度与治疗前比较,差异无统计学意义(P>0.05)。Pearson相关分析结果显示,血浆CRP水平、PLT均与PCIS呈正相关(r值分别为0.719、0.634,P<0.05)。结论重症肺炎并脓毒血症患儿血浆CRP水平和PLT较高,且其与患儿病情严重程度相关。 Objective To analyze the changes of plasma C-reactive protein (CRP) and platelet count (PLT) in children with severe pneumonia and sepsis and its clinical significance. Methods From January 2013 to October 2015, 89 children with severe pneumonia admitted to Pediatric Intensive Care Unit (ICU) of Baoji MCH Hospital were divided into control group (without sepsis) according to the occurrence of sepsis , n = 34) and observation group (with sepsis, n = 55). Plasma CRP level, PLT and pediatric critical illness score (PCIS) were compared between two groups before and after treatment. Results There was no significant difference in plasma CRP levels between the two groups before treatment (P> 0.05). After treatment, CRP level in children in observation group was higher than that in control group (P <0.05). After treatment, the plasma CRP level in control group was lower than that before treatment (P <0.05), while there was no significant difference in plasma CRP level between the two groups (P> 0.05). The PLT in observation group before treatment was higher than that in control group (P <0.05). There was no significant difference in PLT between the two groups after treatment (P> 0.05). After treatment, PLT in both groups was lower than before treatment (P <0.05). There was no significant difference in the severity of illness between the two groups before and after treatment (P> 0.05). After treatment, the severity of illness in the control group was less than that before treatment (P <0.05) There was no significant difference between the severity and before treatment (P> 0.05). Pearson correlation analysis showed that plasma CRP levels and PLT were positively correlated with PCIS (r = 0.719,0.634, P <0.05, respectively). Conclusion Serum CRP levels and PLT in children with severe pneumonia and sepsis are higher than those in children with severe pneumonia and sepsis.