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目的分析陕西省2006-2015年百日咳流行特征及人群抗体水平,为防控策略制定提供参考依据。方法通过描述性方法分析我省近10年百日咳发病特征变化,用酶联免疫吸附实验检测人群血清百日咳抗体水平。结果陕西省2006-2015年百日咳发病整体呈上升趋势,2015年发病率达到1.96/10万,近10年百日咳发病人群主要为0岁组人群,占比67.60%,2014、2015两年关中地区发病率升高明显,百日咳发病时间分布仍主要集中在5~9月份,但由原来的双峰分布变为近年的单峰分布。960份健康人群血清标本Ig G抗体几何平均浓度22.47 IU/ml,阳性701例,阳性率73.02%,3~5岁和6~9岁组抗体几何平均浓度低于其他年龄组,差异具有统计学意义(F=22.73,P<0.001)人群抗体水平整体呈高转低再升高的趋势。结论陕西省近年来百日咳发病有升高趋势,同时发病特征有所改变,人群抗体监测发现3~9岁组抗体水平低下,下一步应加强疾病监测敏感性并针对重点地区和易感人群采取必要防控措施。
Objective To analyze the prevalence and population of pertussis in Shaanxi Province from 2006 to 2015 and provide a reference for the development of prevention and control strategies. Methods By descriptive method analysis of the incidence of pertussis in our province in recent 10 years, the changes in the characteristics of the enzyme-linked immunosorbent assay serum levels of whooping cough. Results The overall incidence of pertussis increased from 2006 to 2015 in Shaanxi Province, with a prevalence of 1.96 / 100 000 in 2015. The incidence of pertussis in the recent 10 years was mainly in the 0-year-old group, accounting for 67.60%. In 2014 and 2015, The rate of increase obviously, pertussis onset time distribution is still mainly concentrated in May to September, but from the original bimodal distribution into a single peak distribution in recent years. The average geometric mean concentration of Ig G antibody in 960 healthy volunteers was 22.47 IU / ml, with a positive rate of 73.02%. The geometric mean concentrations of antibody in 3 ~ 5 and 6 ~ 9 years old groups were lower than those in other age groups. The difference was statistically significant Significance (F = 22.73, P <0.001) antibody levels in the population showed a trend of high turning low and then increasing. Conclusions In recent years, the incidence of pertussis in Shaanxi Province has been on the rise. At the same time, the characteristics of the disease have been changed. Antibody monitoring in the population shows that antibody levels are low in the age group of 3 to 9 years old. Sensitivity of disease surveillance should be strengthened in the next step and necessary for key areas and susceptible populations Prevention and control measures.