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目的观察快速康复外科(FTS)技术对结、直肠癌患者围术期外周血辅助性T细胞表达影响。方法选择2010年1月-2010年12月在我院普外科住院且接受结、直肠癌根治切除手术患者67例,并随机分为FTS组(34例)和对照组(同期手术,未接受FTS治疗患者,33例),观察入选患者围术期辅助性T细胞(CD3+、CD4+、CD8+、CD4+/CD8+)表达水平。结果两组患者手术前外周血CD3+、CD4+、CD8+表达水平及CD4+/CD8+比值接近(P均>0.05)。术后第1d,两组患者外周血CD3+、CD4+、CD8+表达水平及CD4+/CD8+比值明显低于手术前,FTS组大部分外周血CD3+、CD4+、CD8+表达水平及CD4+/CD8+比值明显高于对照组(P均<0.05)。术后第1周,两组患者外周血CD3+、CD4+、CD8+表达水平及CD4+/CD8+比值明显明显高于术后第1d检测结果,同时FTS组大部分外周血CD3+、CD4+、CD8+表达水平及CD4+/CD8+比值明显高于对照组(P均<0.05)。结论 FTS技术可明显影响结、直肠癌根治术患者辅助性T细胞表达程度。
Objective To observe the effect of rapid rehabilitation surgery (FTS) on peripheral blood helper T cells in patients with colorectal cancer and rectal cancer. Methods From January 2010 to December 2010, 67 patients hospitalized in our hospital and underwent radical resection of colorectal cancer undergoing radical surgery were randomly divided into FTS group (34 cases) and control group (same surgery, no FTS (33 cases). The expression of helper T cells (CD3 +, CD4 +, CD8 +, CD4 + / CD8 +) during the perioperative period was observed. Results The levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + in the peripheral blood of the two groups before operation were similar (all P> 0.05). The expression of CD3 +, CD4 +, CD8 + and the ratio of CD4 + / CD8 + in the peripheral blood of the two groups were significantly lower than those before operation on the first postoperative day. The levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + Group (all P <0.05). At the first week after operation, the expression of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + in the peripheral blood of the two groups were significantly higher than those at the first day after operation. Meanwhile, the expression of CD3 +, CD4 +, CD8 + / CD8 + ratio was significantly higher than the control group (all P <0.05). Conclusion FTS can significantly affect the expression of helper T cells in patients with radical resection of rectal cancer.