【摘 要】
：
DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes,inducing gene silencing.Realgar(
【机 构】
：
Research Center,Xiyuan Hospital,China Academy of Chinese Medical Sciences and Beijing Key Lab of Tra
论文部分内容阅读
DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes,inducing gene silencing.Realgar(α-As4S4)is a traditional medicine used for the treatment of various diseases in the ancient time.Realgar was reported to have efficacy for acute promyelocytic leukemia(APL).It has been demonstrated that realgar could efficiently reduce DNA hypermethylation of MDS.This review discusses the mechanisms of realgar on inhibiting DNA hypermethylation of MDS,as well as the species and metabolisms of arsenic in vivo.
其他文献
Objective:To analyze the intellectual landscape and emerging research trends of Chinese medicine(CM) in the management of pediatric asthma through a scientometric study.Methods:Publications related to CM in the management of pediatric asthma were retrieve
Objective:To elucidate the mechanisms of 4 effective components from a Chinese medicine formula,namely Qingre Huoxue Jiedu Formula(QHJ heat-and toxin-clearing and blood-activating formula),in the treatment of nerve growth factor(NGF)-induced psoriasis.Met
Alzheimer\'s disease(AD)is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80％of all dementias.The pathogenesis of AD is complicated and enigmatic thus far.The mitochondrial cascade hypothesis assumes that
Objective:To compare the safety differences between Chinese medicine (CM) and Western medicine (WM) based on Chinese Spontaneous Reporting Database (CSRD).Methods:Reports of adverse events (AEs) caused by CM and WM in the CSRD between 2010 and 2011 were s
农村经济的发展带动了高科技畜牧业的发展,与传统畜牧业相比,高科技畜牧业具有更明显的优势.畜牧业为人民群众提供了充足的物资保障,推动畜牧业发展,使其为社会进步、人民群众的生活水平提高作出更大的贡献.本文着重分析了我国畜牧业的现状和兽医技术的推广.结合我国兽医技术发展的实际需要,对基层养殖和兽医新技术推广体系的构建进行了相应的研究.结合新技术推广过程中存在的问题,制定了具体的兽医技术推广条例,全面提高技术推广的有效性.
Objective:To analyze the available data on the anti-anger effects of herbal medicines(HMs)as well as their underlying mechanisms in rat models.Methods:From 6 electronic databases[PubMed,EMBASE,China National Knowledge Infrastructure(CNKI),Wanfang,Oriental
非洲猪瘟病毒已经在国内定植,为此农业农村部2020年在全国推进建设非洲猪瘟无疫小区创建,非洲猪瘟无疫小区创建是实施动物疫病区域化管理的重要手段,是控制和消灭动物疫病的国际通行做法,是我国实现非洲猪瘟常态化防控重要途径.本文就创建过程中对猪场存在的诸多问题进行分析,找出解决的途径,为非洲猪瘟无疫小区创建及疫病净化推广提出解决办法.
目的:基于《黄帝内经》五运六气理论研究吉林省延边地区妇科病高发岁运年份及其与气象要素的相关性.方法:选取2004年1月21日至2014年1月19日吉林省延边地区10年妇科病入院病例资料与同期气象资料,运用描述性统计分析、卡方检验研究妇科病在不同岁运时段发病数是否有统计学差异;选取妇科病发病最高的岁运时段数据,采用主成分分析法提取主要气象因子得到成分矩阵,进行旋转分析,探讨妇科病与气象要素之间的相关性.结果:吉林省延边地区妇科病在火运不及之年发病数最高与同期气象要素中气温、湿度和气压3种气象要素有相关性.结
Objective:To investigate the protective effects of modified Linggui Zhugan Decoction(MLZD),a traditional Chinese medicine formula,on obese type 2 diabetes mellitus (T2DM) rats.Methods:Fifty Sprague-Dawley rats were randomly divided into 5 groups by a rand
In the fight against epidemic infectious diseases in the past 2,000 years,Chinese medicine (CM)has gradually developed a complete response system including diagnosis and treatment.The focal point of CM in the treatment of infectious diseases is the person