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目的探讨血清C-反应蛋白(CRP)和前白蛋白(PA)在新生儿感染性疾病中的变化及临床意义。方法应用比浊法对100例患细菌感染性疾病新生儿及60例生理性黄疸新生儿于治疗前后抽取静脉血进行CRP、前白蛋白(PA)和血沉(ESR)测定。结果新生儿感染性疾病中血清CRP、PA水平和ESR水平增高,尤以细菌感染组增高更明显(P<0.01);治疗后CRP和PA水平下降明显(P<0.01),而ESR下降不明显(P>0.05);血清CRP与PA水平呈负相关(γ=-0.67,P<0.05)。结论测定血清CRP和PA水平的变化可作为新生儿感染的指标之一,动态观察CRP和PA水平的变化有助于观察患儿疾病的演变和治疗的效果判定。
Objective To investigate the changes and clinical significance of serum C-reactive protein (CRP) and prealbumin (PA) in neonatal infectious diseases. Methods Nephelometry was performed on 100 neonates with bacterial infectious disease and 60 neonates with physiological jaundice before and after treatment. The levels of CRP, prealbumin (PA) and erythrocyte sedimentation rate (ESR) were measured by turbidimetry. Results Serum levels of CRP, PA and ESR were higher in neonatal infectious diseases, especially in bacterial infection group (P <0.01). The levels of CRP and PA decreased significantly (P <0.01), while the decrease of ESR was not significant (P> 0.05). There was a negative correlation between serum CRP and PA levels (γ = -0.67, P <0.05). Conclusion The changes of serum CRP and PA levels can be used as one of the indicators of neonatal infection. Dynamic observation of the changes of CRP and PA levels may help to observe the evolution of disease and the effect of treatment.