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目的研究分析早期应用小剂量多巴胺联合呋塞米治疗心功能Ⅲ~Ⅳ级心力衰竭的有效性及安全性。方法 94例心功能Ⅲ~Ⅳ级心力衰竭患者,随机将其分成研究组与对照组,各47例。研究组治疗中给予早期应用小剂量多巴胺与呋塞米联合治疗,对照组治疗中单纯应用呋塞米进行治疗。比较两组患者的治疗效果。结果治疗后,研究组总有效率为95.74%,高于对照组的78.72%,差异具有统计学意义(P<0.05)。研究组脑钠肽(BNP)水平低于对照组,差异具有统计学意义(P<0.05);两组血钾、血钠水平对比,差异均无统计学意义(P>0.05)。研究组的肾功能损害、利尿剂抵抗、死亡发生率均低于对照组,差异均具有统计学意义(χ~2=3.8588、3.8588、4.1778,P<0.05)。结论心功能Ⅲ~Ⅳ级心力衰竭患者的临床治疗中早期应用小剂量多巴胺与呋塞米联合治疗,临床效果显著。
Objective To study the effectiveness and safety of early application of low-dose dopamine combined with furosemide in the treatment of heart failure with grade Ⅲ ~ Ⅳ heart failure. Methods A total of 94 patients with heart failure Ⅲ ~ Ⅳ grade heart failure were randomly divided into study group and control group, with 47 cases in each group. In the study group, low-dose dopamine and furosemide combined with early treatment were given in the treatment group. Furosemide alone was used in the control group. The treatment effect of two groups of patients was compared. Results After treatment, the total effective rate of the study group was 95.74%, which was higher than that of the control group (78.72%). The difference was statistically significant (P <0.05). The level of BNP in the study group was lower than that in the control group (P <0.05). There was no significant difference in serum potassium and serum sodium between the two groups (P> 0.05). The incidence of renal dysfunction, diuretic resistance and death in the study group were lower than those in the control group (χ ~ 2 = 3.8588,3.8588,4.1778, P <0.05). Conclusion Clinical application of small dose of dopamine and furosemide in the early stage of clinical treatment of heart failure patients with grade Ⅲ ~ Ⅳ heart failure has a significant clinical effect.