自1969年Flangan报告先天性无胸腺小鼠——裸鼠(Nude Mice)以来,这种动物已广泛应用于免疫学,遗传学和肿瘤学等多方面研究。1976年Colston和Kohsaka首先报告应用裸鼠作实验麻风动物模型(简称裸鼠模型)的研究,其后又有不少学者进行了深入的研究。至今裸鼠模型已被公认,并在麻风免疫、实验化疗、传播途径等方面的研究以及作为保存菌种及麻风杆菌来源等方面起着不可忽视的作用。 Since the 1969 report by Flangan on congenital athymic mice, Nude Mice, it has been used extensively in immunology, genetics and oncology. In 1976, Colston and Kohsaka first reported the study of nude mice using experimental leprosy animal model (hereinafter referred to as nude mouse model), and many other scholars conducted in-depth research thereafter. Up to now, the nude mouse model has been recognized and plays an important role in the research of leprosy immunity, experimental chemotherapy and transmission, as well as the preservation of bacteria and the source of leprosy.