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目的探讨同型半胱氨酸(homocysteine,Hcy)及叶酸、维生素B12与深静脉血栓(deep venous thrombosis,DVT)的关系。方法采用病例对照研究的方法,对50例确诊为DVT的患者及来自同一地区、性别、年龄匹配的50例对照,调查流行病学资料,同时检测血中Hcy、叶酸、维生素B12含量,分析其与DVT形成之间的关系。结果血浆高同型半胱氨酸(HHcy)水平、血中叶酸水平低下与DVT发生的关系有统计学意义,OR分别为3.74(1.21～11.59)、0.17(0.05～0.53)。血中叶酸水平与Hcy水平相关,偏相关系数为-0.21,P值为0.04;维生素B12水平与叶酸水平相关,偏相关系数为0.31,P值为0.002。结论血浆HHcy水平与DVT发生的危险性增高呈正相关;血中叶酸和维生素B12水平与DVT发生的危险性呈负相关;低叶酸水平不仅通过增加血Hcy水平,而且可能通过其他机制,增加DVT发生的危险性;血中维生素B12水平低下主要是通过影响叶酸水平,引起HHcy,进而增加DVT发生的危险性。
Objective To investigate the relationship between homocysteine (Hcy), folic acid, vitamin B12 and deep venous thrombosis (DVT). Methods A case-control study was conducted to investigate the epidemiological data of 50 patients diagnosed as DVT and 50 controls matched by gender and age from the same area. Meanwhile, the content of Hcy, folic acid and vitamin B12 in blood were detected and analyzed Relationship with DVT formation. Results The plasma Homocysteine (HHcy) level and the blood level of folic acid were significantly correlated with DVT (OR = 3.74, 1.21-11.59, 0.17, 0.05-0.53, respectively). Blood levels of folic acid correlated with Hcy level, with a partial correlation coefficient of -0.21 and a P value of 0.04. Vitamin B12 level was correlated with folic acid level with a partial correlation coefficient of 0.31 and a P value of 0.002. Conclusions There is a positive correlation between plasma HHcy levels and the increased risk of DVT. The levels of blood folic acid and vitamin B12 are negatively correlated with the risk of developing DVT. Low folate levels may not only increase blood Hcy levels but also increase the occurrence of DVT through other mechanisms Of the risk; blood vitamin B12 levels mainly through the impact of folic acid levels, causing HHcy, thereby increasing the risk of DVT occurred.