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现代创新药物研发是多学科协作的系统工程,而结构新颖、活性显著、机制明确的先导物发现,无疑是新药研发链的关键环节,这不但是实现新药源头创新的前提,也是影响创新药物研发周期和成功率的决定性因素。中药及天然药物活性成分因其多样的骨架结构和广泛的生物活性一直是药物研发的重要来源。据统计,在1981—2014年间上市的新药中,有超过1/3直接或间接
Modern innovative drug research and development is a multidisciplinary collaborative systematic project. However, the discovery of a pioneer structure with significant activity and clear mechanism is undoubtedly the key link in the research and development of new drugs. This is not only a prerequisite for the source innovation of new drugs, but also an important factor affecting the research and development of innovative drugs The decisive factor in the cycle and success rate. Traditional Chinese medicine and natural medicine active ingredients because of its diverse skeletal structure and a wide range of biological activity has been an important source of drug development. According to statistics, more than one-third of the new drugs marketed between 1981 and 2014 are direct or indirect