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目的 本实验用不同浓度碘水诱发小鼠高碘甲状腺肿。方法将实验动物随机分为５组，分别饮含碘５０、５００、１０００、２０００、３０００μｇ／Ｌ的去离子水。喂至３月龄，观察小鼠甲状腺和血清学变化。结果碘离子５００μｇ／Ｌ就可诱发小鼠高碘甲状腺肿。随着碘离子浓度的升高甲状腺绝对重量和相对重量有增大趋势。光镜观察，甲状腺肿为胶质性甲状腺肿。血清学改变为，Ｔ４、ｒＴ３升高，Ｔ３变化不明显。随着碘浓度的升高，Ｔ４、ｒＴ３有升高趋势，但无统计学意义。结论 碘离子浓度达到５００μｇ／Ｌ时，就可诱发高碘甲状腺肿。
Objective This experiment used different concentrations of iodine water to induce mice with high iodine goiter. Methods Experimental animals were randomly divided into five groups, respectively, drinking iodine 50,500,1000,2000,3000 μg / L of deionized water. Fed to 3 months old mice observed thyroid and serological changes. Results Iodine 500μg / L can induce high iodine goiter in mice. With the increase of iodine ion concentration, the absolute weight and relative weight of thyroid tend to increase. Light microscopy, goiter as a gliacyte. Serological changes, T4, rT3 increased, T3 was not obvious. With the increase of iodine concentration, T4, rT3 have an increasing trend, but no statistical significance. Conclusion When the iodine ion concentration reaches 500μg / L, it can induce high iodine goiter.