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目的探讨阿托伐他汀对老年高血压患者血清C反应蛋白(CRP)、内皮素水平的影响。方法选取2010年4月—2014年10月海口市人民医院诊治的老年高血压患者160例为高血压组,同期健康体检者120例为对照组,血压120~139/80~89 mm Hg者120例为正常高值组。高血压组患者采用阿托伐他汀治疗,比较3组患者血清CRP、内皮素、一氧化氮(NO)和N末端脑钠肽前体(NT-proBNP)水平及收缩压、舒张压、心率、射血分数。结果高血压组患者治疗前后血清CRP、内皮素、NT-proBNP水平均高于对照组和正常高值组,血清NO水平低于对照组和正常高值组(P<0.05);高血压组患者治疗后血清CRP、内皮素水平均低于治疗前(P<0.05);高血压组患者治疗前后血清NO、NT-proBNP水平比较,差异无统计学意义(P>0.05)。高血压组患者治疗前后收缩压、舒张压、心率均高于对照组和正常高值组,射血分数低于对照组和正常高值组(P<0.05);高血压组患者治疗后收缩压、舒张压、心率均低于治疗前,射血分数高于治疗前(P<0.05)。结论老年高血压患者血清CRP、内皮素、NO、NT-proBNP水平存在异常,而阿托伐他汀主要通过调节CRP、内皮素而达到治疗老年高血压的效果。
Objective To investigate the effects of atorvastatin on serum C-reactive protein (CRP) and endothelin levels in elderly patients with hypertension. Methods 160 elderly hypertensive patients diagnosed and treated in Haikou People’s Hospital from April 2010 to October 2014 were selected as the hypertension group and 120 healthy subjects were selected as the control group. The blood pressure was 120 ~ 139/80 ~ 89 mm Hg 120 Example for the normal high value group. Patients in the hypertensive group were treated with atorvastatin. Serum levels of CRP, endothelin, nitric oxide (NO), NT-proBNP and systolic blood pressure, diastolic blood pressure, heart rate, Ejection fraction. Results The levels of serum CRP, ET-1 and NT-proBNP in patients with hypertension were significantly higher than those in controls and normal subjects (P <0.05). The levels of serum NO in patients with hypertension were significantly lower than those in controls and normal subjects (P <0.05) After treatment, serum CRP and endothelin levels were lower than before treatment (P <0.05). There was no significant difference in serum NO and NT-proBNP levels between the two groups before and after treatment (P> 0.05). The systolic blood pressure, diastolic blood pressure and heart rate of hypertensive patients before and after treatment were higher than those of the control group and the normal high-value group, and the ejection fraction was lower than that of the control group and the normal high-value group (P <0.05) , Diastolic blood pressure, heart rate were lower than before treatment, ejection fraction higher than before treatment (P <0.05). Conclusions The levels of CRP, ET, NO and NT-proBNP in elderly patients with hypertension are abnormal. Atorvastatin can be used to treat elderly hypertension mainly through regulating CRP and endothelin.