冠心病是冠状动脉粥样硬化引起的心脏病,主要是由于脂质沉积于血管壁造成冠状动脉狭窄或阻塞,引起的心肌缺血和供氧不足,近年来逐渐呈现年轻化趋势。冠脉动脉血管支架等介入治疗利用导管和球囊疏通狭窄闭塞的冠状动脉管腔,改善心肌的血流灌注,能够迅速有效地缓解病情,挽救患者的生命,是治疗缺血性心脏病、动脉内膜增生等心血管疾病的有效手段。由于血管支架等介入治疗不可避免地对血管壁造成一定的损伤并破坏内皮层,因此术后常伴随着急性和亚急性血栓形成、内膜增生、再狭窄等不良事件的发生。研究表明,损伤血管段的再内皮化直接决定了术后愈合的效果,而再内皮化的修复速率取决于介入治疗对血管的损伤程度及局部的微环境。本文就再内皮化的细胞来源、血管损伤程度、血流动力学改变等影响血管介入治疗后再内皮化修复速率的研究进展进行综述。 Coronary heart disease is coronary heart disease caused by atherosclerosis, mainly due to lipid deposition in the vessel wall caused by coronary artery stenosis or obstruction, resulting in myocardial ischemia and lack of oxygen in recent years gradually showing a younger trend. Coronary artery stent and other interventional treatment using catheter and balloon to clear the narrow occlusion of the coronary lumen and improve myocardial perfusion can quickly and effectively alleviate the condition and save the patient’s life is the treatment of ischemic heart disease, Endometrial hyperplasia and other cardiovascular disease effective means. Because of the intervention of vascular stents and other inevitable vascular wall damage and damage the endothelium, so often accompanied by acute and subacute thrombosis, intimal hyperplasia, restenosis and other adverse events. Studies have shown that re-endothelialization of damaged blood vessels directly determines the effect of postoperative healing, and the rate of re-endothelialization depends on the degree of damage to blood vessels and the local microenvironment of the interventional treatment. This review summarizes the research progress of the endothelialization rate, such as the origin of the endothelial cells, the degree of vascular injury and hemodynamic changes, which influence the endothelialization rate after vascular intervention.