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目的:评价头孢噻肟钠对肝硬化上消化道出血患者院内感染的防治作用。方法:选取2015年1月—2017年1月期间收治的肝硬化上消化道出血患者120例临床资料,按随机数表法将其分为基础组和预防组(每组60例);基础组患者给予常规基础治疗,预防组患者在基础组治疗基础上加用头孢噻肟钠治疗,比较两组患者用药后院内感染的发生情况。结果:预防组患者用药后住院时间优于基础组(P<0.05),感染率、再出血率、病死率和自发性腹膜炎的发生率均低于基础组(P<0.05);治疗前两组患者的C-反应蛋白(CRP)与白细胞计数(WBC)测得值经组间比较其差异无统计学意义(P>0.05),治疗后预防组患者CRP、WBC测得值均低于基础组(P<0.05)。结论:头孢噻肟钠对肝硬化上消化道出血患者院内感染具有防治作用,可有效地缩短患者的住院时间,降低了感染率、再出血率、病死率及自发性腹膜炎的发生率。
Objective: To evaluate the prevention and treatment of cefotaxime sodium in patients with cirrhosis and upper gastrointestinal bleeding. Methods: The clinical data of 120 patients with cirrhosis and upper gastrointestinal bleeding admitted from January 2015 to January 2017 were selected and divided into basic group and preventive group (60 cases in each group) according to the random number table method. The basic group Patients were given routine basic treatment. Patients in prevention group were treated with cefotaxime sodium on the basis of basic treatment. The incidence of nosocomial infection in both groups was compared. Results: The hospitalization time of the prophylaxis group was better than that of the basic group (P <0.05), and the infection rate, rebleeding rate, mortality and spontaneous peritonitis were lower than those of the basic group (P <0.05) There was no significant difference between the two groups in CRP and WBC (P> 0.05). The CRP and WBC in the prevention group were lower than those in the basic group (P <0.05). Conclusion: Cefotaxime sodium has preventive and therapeutic effects on nosocomial infections in cirrhotic patients with upper gastrointestinal bleeding, which can shorten the length of hospital stay and reduce the incidence of infection, rebleeding, mortality and spontaneous peritonitis.