目的探讨以神经系统损害为首发症状的急性白血病的临床特征。方法对12例患者的临床资料进行回顾性分析。结果12例中首发症状为颅高压型4例,脑实质受压型3例,脊髓损害型2例,周围神经损害型2例,混合型1例。结论以神经系统损害为首发症状的急性白血病在早期易被误诊。 Objective To investigate the clinical features of acute leukemia with neurological damage as the first symptom. Methods The clinical data of 12 patients were retrospectively analyzed. Results The initial symptoms in 12 cases were 4 cases of intracranial hypertension, 3 cases of parenchymal compression, 2 cases of spinal cord injury, 2 cases of peripheral nerve damage and 1 case of mixed type. Conclusion Acute leukemia with neurological damage as the first symptom is easily misdiagnosed in the early stage.