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目的:评价力尔凡对直肠癌MMP蛳7表达的影响及临床意义。方法:将32例低位直肠癌患者随机分为力尔凡治疗组与对照组,治疗组在术前瘤体内注射力尔凡后接受手术治疗,对照组仅接受手术治疗,并通过免疫组化法分别检测两组MMP蛳7的表达。结果:MMP蛳7在对照组与力尔凡治疗组的表达明显高于对照组,分别为85.7 %,68.7 %,有显著性差异;对照组中Dukes B期和C期MMP蛳7的表达有显著性差异。结论:术前瘤体内注射力尔凡,可明显降低直肠癌MMP蛳7的表达,在Dukes C期比B期更明显。
Objective: To evaluate the effect of Rilvan on the expression of MMP-7 in rectal cancer and its clinical significance. Methods: Thirty-two patients with low rectal cancer were randomly divided into Lilvan treatment group and control group. The treatment group received surgery before surgery and the control group received only surgical treatment. Immunohistochemistry The expression of MMP-7 in two groups were detected. Results: The expression of MMP-7 in control group and Lilvan treatment group was significantly higher than that in control group (85.7%, 68.7%, respectively). The expression of MMP-7 in Dukes B phase and C phase in control group was Significant difference. Conclusions: The preoperative injection of Li Er Fan can significantly reduce the expression of MMP 蛳 7 in rectal cancer, and is more obvious in stage Dukes C than in stage B.