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目的比较两组三联药物治疗消化性溃疡及根除幽门螺杆菌的疗效,指导临床合理用药。方法治疗组给予奥美拉唑20 mg,2次/d,克拉霉素0.5 g,2次/d,阿莫西林1.0 g,2次/d,连服1周,然后继续服用奥美拉唑20 mg,1次/d,连服4周;对照组给予雷尼替丁150 mg,2次/d,甲硝唑0.4 g,2次/d,阿莫西林1.0 g,2次/d,连服2周,然后继续服用雷尼替丁150 mg,2次/d,连服6周。结果治疗组溃疡治愈率、总有效率及幽门螺杆菌转阴率均高于对照组,差异均有统计学意义(P<0.05)。结论奥美拉唑、克拉霉素、阿莫西林三联疗法治疗消化性溃疡,疗效显著。
Objective To compare the curative effect of two groups triple therapy on peptic ulcer and eradication of Helicobacter pylori to guide clinical rational drug use. Methods Omeprazole 20 mg twice daily, clarithromycin 0.5 g twice daily and amoxicillin 1.0 g twice daily for 1 week were given to the treatment group. Omeprazole 20 mg once daily for 4 weeks. The control group was treated with ranitidine 150 mg twice daily, metronidazole 0.4 g twice daily, amoxicillin 1.0 g twice daily, Even for 2 weeks, and then continue to take ranitidine 150 mg, 2 times / d, and even served 6 weeks. Results The ulcer cure rate, total effective rate and Helicobacter pylori negative rate in the treatment group were higher than those in the control group, with significant differences (P <0.05). Conclusion Omeprazole, clarithromycin, amoxicillin triple therapy for the treatment of peptic ulcer, a significant effect.