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目的探讨血尿酸与高血压(HT)、代谢综合征(MS)及其组分之间的关系。方法山东沿海地区成年常住居民4114名,按血尿酸浓度从低到高分为4组(Q1～Q4),分析血尿酸与HT、MS及其组分之间的关系。结果血尿酸与年龄、收缩压、舒张压、甘油三酯、胆固醇、空腹血糖、腰围、臀围及体质指数正相关,与性别、高密度脂蛋白胆固醇负相关;HT和MS的患病率随血尿酸的升高而升高(趋势P<0.01),男性血尿酸最高的Q4组发生HT和MS的相对危险度分别是血尿酸最低的Q1组的1.72(95%CI 1.31～2.27)倍和4.59(95%CI 3.09～6.81)倍,女性分别为2.03(95%CI 1.55～2.66)倍和4.09(95%CI 3.09～6.81)倍(P<0.01);血尿酸与MS的各组分密切相关(P<0.01),但Logistic回归分析显示高尿酸血症不是MS的独立危险因素(P>0.05)。结论血尿酸升高正相关于HT和MS的患病率,血尿酸与MS各组分密切相关。
Objective To investigate the relationship between uric acid and hypertension (HT), metabolic syndrome (MS) and its components. Methods 4114 adult residents in Shandong coastal area were divided into 4 groups (Q1 ~ Q4) according to the concentration of serum uric acid, and the relationship between serum uric acid, HT, MS and their components was analyzed. Results Serum uric acid was positively correlated with age, systolic blood pressure, diastolic blood pressure, triglyceride, cholesterol, fasting blood glucose, waist circumference, hip circumference and body mass index, but negatively correlated with sex and high density lipoprotein cholesterol. (P <0.01). The relative risk of HT and MS in Q4 with the highest level of serum uric acid were 1.72 (95% CI 1.31 ~ 2.27) times of that in the lowest level of serum uric acid 4.59 (95% CI 3.09-6.81) times, 2.03 (95% CI 1.55-2.66) and 4.09 (95.9% CI 3.09-6.81), respectively (P <0.01). The contents of serum uric acid and MS were close (P <0.01). However, Logistic regression analysis showed that hyperuricemia was not an independent risk factor for MS (P> 0.05). Conclusions The elevated serum uric acid is positively related to the prevalence of HT and MS. Serum uric acid and MS are closely related to each other.