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利用乳化交联法制备了1,2-苯并异噻唑啉-3-酮-壳聚糖缓释微球,通过扫描电子显微镜(SEM)、动态光散射(DLS)、傅里叶变换红外光谱(FT-IR)、X射线衍射和热重-差热分析等检测手段考察分析了微球的性能,并通过体外模拟释放探讨了其控释性能。结果表明:所制备的微球表面光滑,成球性好,分散性能优异,微球粒径主要集中在3~8μm范围内,BIT分子以物理包埋的方式与壳聚糖分子之间相结合,并被壳聚糖分子完全包裹;模拟释放实验表明,BIT-CSM可实现BIT的长期稳定释放,具有一定的控释效果。
The 1,2-benzisothiazolin-3-one-chitosan microspheres were prepared by emulsion cross-linking method. The microspheres were characterized by scanning electron microscopy (SEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetry-differential thermal analysis (DTA) were used to investigate the properties of the microspheres. The results show that the prepared microspheres have a smooth surface, good sphericity and excellent dispersion performance. The microspheres mainly concentrate in the range of 3 ~ 8μm, and the BIT molecules are physically entrapped with chitosan molecules , And was completely encapsulated by chitosan molecules. Simulated release experiments showed that BIT-CSM could achieve long-term stable release of BIT with certain controlled release effect.