【摘 要】
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The synthesis of a cytotoxic natural ester sintenin 1 and thirty-three of its analogues 2-34 were carried out. The cytotoxicities of the synthetic compounds hav
【机 构】
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Department of Traditional Chinese Medicine and Natural Drug Research,Zhejiang Hisun Naturelite Pharm
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The synthesis of a cytotoxic natural ester sintenin 1 and thirty-three of its analogues 2-34 were carried out. The cytotoxicities of the synthetic compounds have been screened for human tumor cell lines such as PC-3, Hela, A549, BEL7404, CNE, and KB. The results showed that phenolic derivatives exhibited strongest cytoxicity, and the unsaturated esters were more cytotoxic than their saturated analogues.
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