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目的观察药学干预方式指导降血脂药物合理应用的临床效果。方法应用降血脂药物治疗的患者138例随机均分为两组:药学干预组采用药学干预方式指导患者合理应用降血脂药物,具体内容包括制定规范、加强处方管理、重视用药知识宣教和实行定期考核制度。常规指导组仅给予常规服药指导。检测血脂水平,统计降血脂药物不合理用药率,记录不良反应发生情况。结果两组患者治疗后,TC、LDL-C和TG均较治疗前降低,HDL-C升高(P<0.05),药学干预组血脂水平改善大于常规指导组(P<0.05)。药学干预组患者降血脂药物用药不合理发生率低于常规指导组(7.25%vs.23.19%)(P<0.01)。降血脂药物应用相关不良反应主要是恶心呕吐、心律失常和腹泻;药学干预组不良反应发生率低于常规指导组(4.35%vs.24.64%)(P<0.05)。结论实施降血脂药物应用的药学干预能有效提高合理用药率和临床治疗效果,降低不良反应发生率。
Objective To observe the clinical effect of pharmacological intervention on the rational use of antihyperlipidemic drugs. Methods One hundred and thirteen patients with hypolipidemic drugs were randomly divided into two groups: Pharmacological intervention group used pharmacological interventions to guide the rational use of antihypertensive drugs. The specific contents included formulating norms, strengthening prescription management, paying attention to knowledge of drug use and carrying out regular assessment system. General guidance group only give regular medication guidance. Blood lipid levels were measured, statistics of unreasonable drug use rate of hypolipidemic drugs were recorded, and the incidence of adverse reactions was recorded. Results After treatment, TC, LDL-C and TG in both groups were lower than those before treatment and HDL-C was increased (P <0.05). The level of serum lipids in the intervention group was higher than that in the conventional group (P <0.05). Pharmacological intervention group of patients with lipid-lowering drugs lower than the incidence of unreasonable medication guidance group (7.25% vs.23.19%) (P <0.01). The adverse reactions associated with hypolipidemic drugs were mainly nausea and vomiting, arrhythmia and diarrhea. The incidence of adverse reactions in the pharmacological intervention group was lower than that in the conventional group (4.35% vs.24.64%, P <0.05). Conclusion The implementation of pharmacological interventions for lowering blood lipid can effectively improve the rational use rate and clinical effect and reduce the incidence of adverse reactions.