本文就国内外对口服避孕药是否造成染色体异常、影响胚胎发育和导致先天性畸形等出生缺陷疾病(如先天性心脏病、肢体短缺畸形、尿道和前列腺畸形、神经系统畸形、食管闭锁、多/并指(趾)畸形、变态反应性疾病、女性胎儿男性化、唐氏综合征等)进行了综述。 In this paper, whether oral contraceptives caused chromosomal abnormalities at home and abroad, affecting embryonic development and congenital malformations and other birth defects (such as congenital heart disease, short limb deformity, urethral and prostate deformities, nervous system deformity, esophageal atresia, And finger (toe) deformity, allergic diseases, male fetus, Down’s syndrome, etc.) were reviewed.