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85例高 IgA 血症中单纯 IgA 增高52例,IgA 并 IgG 增高28例,IgA 并IgM 增高5例,男、女之比为1.58∶1,74.1％(63例)患儿年龄>7岁;95.3％(81例)的患儿血清 IgA 呈轻～中度增高。其相关疾病包括肾小球疾病48例、风湿热或风湿性心脏病17例、过敏性紫癜10例、其他自身免疫性疾病7例及其他疾患3例。大多数病儿血清 IgA 增高伴有血沉、循环免疫复合物、抗链球菌溶血素“O”抗体增高和血清 C_3水平异常,部分病儿伴有淋巴母细胞转化率降低。提示高 IgA 血症系机体免疫功能紊乱的表现之一。
In 85 cases of hypergammaglobulinemia, IgA increased in 52 cases, IgA and IgG increased in 28 cases, IgA and IgM increased in 5 cases, male to female ratio was 1.58:1, 74.1% (63 cases) children were more than 7 years old; 95.3% (81 cases) of children with serum IgA mild to moderate increase. The related diseases include 48 cases of glomerular disease, rheumatic fever or rheumatic heart disease in 17 cases, 10 cases of allergic purpura, 7 cases of other autoimmune diseases and other diseases in 3 cases. Most of sick children with elevated serum IgA associated with erythrocyte sedimentation rate, circulating immune complexes, anti-streptolysin “O” antibodies and serum C_3 levels abnormalities, some sick children with lymphoblastosis decreased. Prompt hyper IgAmia is one of the manifestations of immune dysfunction.