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目的探讨盐酸哌甲酯控释片(OROS-MPH)联合卡马西平治疗伴中央-颞区棘波良性癫痫(BECTs)合并多动综合征(ADHD)患儿的疗效。方法将BECTs合并ADHD患儿84例随机分为观察组与对照组各42例。两组均接受卡马西平治疗,6个月内脑电图(EEG)稳定后分别加心理行为治疗和心理行为联合OROS-MPH治疗。比较两组临床疗效及不良反应。结果观察组的BECTs总有效率为90.48%,与对照组的92.86%比较差异无统计学意义(P>0.05);观察组的ADHD总有效率为95.24%,显著高于对照组的64.29%(P<0.05);治疗后观察组的PSQ量表评分显著低于对照组(P<0.05)。结论 OROS-MPH联合卡马西平治疗BECTs合并ADH安全可靠,能够有效改善患儿的临床症状。
Objective To investigate the efficacy of ORP-MPH combined with carbamazepine in the treatment of children with central-temporal sporadic benign epilepsy (BECTs) and hyperactivity syndrome (ADHD). Methods Eighty-four children with BECTs and ADHD were randomly divided into observation group (n = 42) and control group (n = 42). Both groups were treated with carbamazepine, EEG was stable within 6 months, respectively, combined with psychological behavior and psychological behavior combined with OROS-MPH treatment. The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate of BECTs in the observation group was 90.48%, which was not significantly different from that of the control group (92.86%) (P> 0.05). The total effective rate of ADHD in the observation group was 95.24%, which was significantly higher than that of the control group (64.29% P <0.05). After treatment, PSQ score in observation group was significantly lower than that in control group (P <0.05). Conclusion OROS-MPH combined with carbamazepine treatment of BECTs combined with ADH safe and reliable, can effectively improve the clinical symptoms of children.