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目的探讨多学科治疗大肠癌肝转移及其预后相关因素。方法采用多因素回归分析方法回顾性分析152例大肠癌肝转移患者的生存因素。结果152例大肠癌肝转移的患者中位生存期为18.5个月,1年生存率为65.3%,3年生存率为21.7%,5年生存率为10.4%。单因素分析显示手术时有否肝转移、肝转移的分期、介入治疗、放疗、物理治疗(PEI、HIFU、射频等)和化疗与患者的生存期显著相关;多因素回归分析发现,介入治疗、物理治疗(PEI、HIFU、射频等)、放疗及肝转移分期是大肠癌肝转移影响预后的主要因素。结论对于大肠癌肝转移的患者进行介入治疗、物理治疗和放疗多学科治疗可以显著提高患者的生存期。
Objective To investigate the multidisciplinary treatment of liver metastasis of colorectal cancer and its related prognostic factors. Methods The multivariate regression analysis was used to analyze the survival factors of 152 patients with liver metastasis from colorectal cancer. Results The median survival time of 152 patients with liver metastasis of colorectal cancer was 18.5 months. The 1-year survival rate was 65.3%, the 3-year survival rate was 21.7%, and the 5-year survival rate was 10.4%. Univariate analysis showed that liver metastasis, stage of liver metastasis, interventional therapy, radiotherapy, physical therapy (PEI, HIFU, radiofrequency and so on) and chemotherapy were significantly correlated with the survival of patients. Multivariate regression analysis showed that interventional therapy, Physical therapy (PEI, HIFU, radiofrequency, etc.), radiotherapy and liver metastasis staging is the main factor affecting the prognosis of liver metastasis of colorectal cancer. Conclusion Interventional therapy for patients with liver metastases from colorectal cancer can significantly improve the survival of patients with multidisciplinary treatment of physical therapy and radiotherapy.