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缩宫素(oxytocin)是一种神经肽,主要由下丘脑的视上核和视旁核合成分泌。外周组织也存在合成缩宫素的细胞,包括心脏。1895年Oliver和Schafer研究了垂体后叶并制备了垂体后叶的活体浸出物,这些浸出物包含了两种不同性质的活性,加压及使子宫收缩。1906年Dale发现牛的垂体后叶浸出液注射孕猫,可引起子宫收缩,以后在孕猴的实验中得到证实,1948年Theobeld首先引入临床静滴
Oxytocin is a neuropeptide that is mainly secreted and synthesized by the supraoptic and para-nucleus of the hypothalamus. Peripheral tissue There are also cells that synthesize oxytocin, including the heart. Oliver and Schafer studied the posterior pituitary gland in 1895 and prepared live extracts of the posterior pituitary gland that contain two different properties of activity, compression, and contraction of the uterus. In 1906, Dale found that the injection of pregnant cat’s leaching solution into the posterior pituitary extract of cattle can cause contraction of the uterus. Later, in the experiment of pregnant monkey, it was confirmed that in 1948, Theobeld first introduced clinical intravenous infusion