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目的探讨缺血性白质脑病患者认知障碍、情感障碍的特点及规律,及对事件相关电位进行研究。方法收集缺血性白质脑病患者480例和正常对照86例,分别应用MMSE和Hamilton焦虑量表和24项版本抑郁量表进行测评,并进行事件相关电位P300、N400检测。结果缺血性白质脑病不同分级认知障碍、情感障碍差异有统计学意义,随着脑白质损害加重、分级增高,认知障碍和情感障碍加重,事件相关电位P300和N400潜伏期明显延长,波幅明显降低。结论缺血性白质脑病可造成患者严重认知、情感障碍,事件相关电位P300、N400可作为早期诊断缺血性白质脑病认知障碍的客观指标。
Objective To investigate the characteristics and rules of cognitive impairment and affective disorder in patients with ischemic leukoencephalopathy, and to study the event-related potentials. Methods A total of 480 patients with ischemic encephalopathy and 86 healthy controls were enrolled in this study. MMSE and Hamilton Anxiety Scale and 24 versions of depression scale were used for evaluation. Event-related potentials P300 and N400 were detected. Results There were significant differences in cognitive impairment and affective disorder between different grades of ischemic leukoencephalopathy. As the white matter damage increased, the grading increased, the cognitive impairment and the affective disorder increased, the incubation period of P300 and N400 of the event-related potentials was significantly prolonged with obvious amplitude reduce. Conclusion Ischemic encephalopathy can cause severe cognitive and affective disorders. Event-related potentials P300 and N400 may serve as objective indicators for the early diagnosis of ischemic leukoencephalopathy.