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采用聚合酶链反应技术（ＰＣＲ）检测流产孕妇下生殖道分泌物和流产胚胎组织的沙眼衣原体（ＣＴ）和解脲支原体（ＵＵ）ＤＮＡ，用酶标双抗体夹心（ＥＬＩＳＡ）法定量测定流产孕妇血清肿瘤坏死因子 α（ＴＮＦα）。结果提示 ＣＴ、ＵＵ宫内感染的流产孕妇在流产前血清ＴＮＦα水平比正常同孕期孕妇明显升高，也显著高于自身流产后该水平（Ｐ＜０． ００１）。下生殖道ＣＴ，ＵＵ感染的先兆流产患者应用红霉素治疗后血清ＴＮＦα水平明显下降，ＣＴ，ＵＵ阴转，患者保胎成功。结果表明ＣＴ，ＵＵ宫内感染可能是引起孕妇流产前血清ＴＮＦα水平异常升高的重要原因。
Chlamydia trachomatis (CT) and Uu DNA were detected by polymerase chain reaction (PCR) in the genital secretions and aborted embryos of abortion pregnant women, and the serum of aborted pregnant women was quantified by enzyme linked immunosorbent assay (ELISA) Tumor necrosis factor alpha (TNFα). The results suggest that CT and UU intrauterine infection of abortion pregnant women before abortion serum TNFα levels than normal pregnant women significantly increased, also significantly higher than the level of spontaneous abortion (P <0.001). Lower genital tract CT, UU infection of threatened abortion patients with erythromycin serum TNFα levels decreased significantly, CT, UU negative turn, the patient miscarriage success. The results showed that CT, UU intrauterine infection may be caused by abnormal serum levels of TNFα in pregnant women before abortion an important reason.