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虽仍不能肯定多巴胺D_2受体的增加是否与患精神分裂症有关或是否完全是精神抑制药的作用,但死后脑组织的研究结果都显示本病多巴胺D_2受体增多。最近注意力已集中于用r或正电子放射性配体和常规断层照相术估计体内D_2受体。 先制备成~(77)Br—溴化螺环哌啶酮(~(77)Br的半衰期为56小时),然后静脉注射5—10毫居里(180-360MBq)。已找到理想的扫描时间为16小时,作者用配备STAR计算机系统的IGE400ATX射线照相机。X射线断层照相机每次扫描时间定为20～40
Although it is still not certain whether the increase of dopamine D 2 receptor is related to schizophrenia or whether it is a complete depressive drug, the results of brain tissue after death show that dopamine D 2 receptor is increased in this disease. Recent attention has focused on estimating D 2 receptors in vivo using either r or positron radioligands and conventional tomography. The ~ (77) Br-spirospiperone (~ (77) Br has a half-life of 56 hours) was then prepared and then injected intravenously 5-10 millicuries (180-360 MBq). The ideal scan time has been found to be 16 hours. The author used an IGE400ATX radiography camera equipped with a STAR computer system. X-ray tomography camera for each scan time set at 20 to 40