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目的探讨冠心病(CHD)患者血浆内皮素-1(ET-1)和血清肌钙蛋白(cTnⅠ)、同型法胱氨酸(Hcy)、一氧化氮(NO)水平的变化及临床意义。方法应用放射免疫发、免疫法和电化学发光法对92例CHD患者进行血浆ET-1和血清cTnⅠ、Hcy、NO水平检测,其中稳定性心绞痛(SAP)40例,不稳定型心绞痛(UAP)35例,急性心肌梗死(AMI)17例,并与90例正常人作比较。结果冠心病患者血浆ET-1和血清cTnⅠ、Hcy水平非常显著地高于正常人组(P<0.01),而NO水平又非常显著地低于正常人组(P<0.01),急性心肌梗死组和不稳定型心绞痛明显高于或低于稳定性心绞痛组(P<0.05),且血清NO水平与ET-1、cTnⅠ、Hcy水平呈显著负相关(r=-0.4912,-0.5028,-0.5924,P<0.01)。结论检测冠心病患者血浆ET-1和血清cTnⅠ、Hcy、NO水平的变化与CHD的发生和发展及疗效和预后观察均具有重要的临床意义。
Objective To investigate the changes and clinical significance of plasma endothelin-1 (ET-1) and serum troponin (cTnⅠ), homocysteine (Hcy) and nitric oxide (NO) in patients with coronary heart disease (CHD) Methods Serum levels of ET-1, serum cTnⅠ, Hcy and NO in 92 CHD patients were measured by radioimmunoassay, immunoassay and electrochemiluminescence. Among them, 40 cases of stable angina pectoris (SAP), unstable angina pectoris (UAP) 35 cases, 17 cases of acute myocardial infarction (AMI), and compared with 90 normal subjects. Results The levels of plasma ET-1 and serum cTnI and Hcy in patients with coronary heart disease were significantly higher than those in normal controls (P <0.01), while the levels of NO were significantly lower than those in normal controls (P <0.01) And unstable angina pectoris were significantly higher or lower than those in stable angina pectoris group (P <0.05), and serum NO levels were negatively correlated with the levels of ET-1, cTn I and Hcy (r = -0.4912, -0.5028, -0.5924, P <0.01). Conclusion The detection of plasma ET-1 and serum levels of cTnⅠ, Hcy and NO in patients with coronary heart disease has important clinical significance in the occurrence and development of CHD and the observation of curative effect and prognosis.