摘要目的 T_1值是评估脑老化过程中的微观结构变化的有效工具。以前的横向研究表明人的一生中,脑白质中T_1值逐渐升高,灰质中T_1值逐渐减低。然而,这些研究结果尚未得到纵向研究基础上的证实。在这超过7年的纵向研究中,T_1值被用来研究老年健康学科中的与年龄相关微结构的动态变化。方法对17例健康受试者(年龄51~77岁)在基线和7年后进行T_1mapping。精确的皮质和白质分割被用来确定皮质和白质的平均T_1值。结果分析显示,7年以后皮质平均T_1值降低,受试者中年龄越大,T_1值减少率越明显。T_1减 Abstract Objective T_1 value is an effective tool to evaluate the changes of microstructure in brain aging. Previous horizontal studies showed that in human life, the T 1 value in white matter gradually increased and the T 1 value in gray matter gradually decreased. However, the results of these studies have not yet been confirmed on the basis of longitudinal studies. In this longitudinal study of more than seven years, the T 1 value was used to study the dynamic changes in age-related microstructures in geriatric health. Methods T_1mapping was performed on 17 healthy subjects (aged 51-77 years) at baseline and 7 years later. Precise cortical and white matter partitioning was used to determine the mean T 1 values ​​for cortex and white matter. Results analysis showed that average cortical T 1 decreased after 7 years. The higher the age of the subjects, the more obvious the decrease of T 1 was. T_1 minus