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目的探讨血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)在胰腺癌淋巴管生成及其与淋巴结转移中的作用。方法采用免疫组织化学染色法,检测42例胰腺癌组织标本和10例正常胰腺组织标本的VEGF-C表达;应用酶组织化学方法检测癌周微淋巴管密度(microlymphatic vessel density,MLVD)。结果胰腺癌VEGF-C的阳性表达率为64．3％,显著高于正常对照组的20％(P<0．05);胰腺癌MLVD为21．93±6．39,显著高于正常对照组的4．40±2．07(P<0．001),VEGF-C表达与肿瘤组织MLVD及淋巴结转移呈正相关(P<0．05)。结论VEGF-C在胰腺癌淋巴管生成及其淋巴结转移中具有重要作用。
Objective To investigate the role of vascular endothelial growth factor C (VEGF-C) in lymphangiogenesis and lymph node metastasis in pancreatic cancer. Methods Immunohistochemical staining was used to detect the expression of VEGF-C in 42 specimens of pancreatic cancer and 10 specimens of normal pancreas. The microlymphatic vessel density (MLVD) was detected by enzyme-linked immunosorbent assay. Results The positive rate of VEGF-C in pancreatic cancer was 64.3%, which was significantly higher than that in the normal control group (P <0.05). The MLVD of pancreatic cancer was 21.93 ± 6.39, which was significantly higher than that of the normal control Group (4.40 ± 2.07, P <0.001). The expression of VEGF-C was positively correlated with MLVD and lymph node metastasis (P <0.05). Conclusion VEGF-C plays an important role in lymphangiogenesis and lymph node metastasis in pancreatic cancer.