【摘 要】
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Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global crisis1,2.Infection from
【机 构】
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School of Pharmaceutical Sciences, Sun Yat-sen University,Guangzhou 510006, China;Institute of Chine
论文部分内容阅读
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global crisis1,2.Infection from SARS-CoV-2 can result in severe lymphopenia, prolonged coagulation profiles, lethal acute respiratory distress syndrome (ARDS), watery diarrhea, cardiac disease, multiorgan dysfunction, and sudden death3,4.Due to its high infectivity and pathogenicity, to date, more than 100,000,000 positive cases and 500,000 deaths were reported, taking away thousands of lives each day.However, there are no specific drugs or vaccines proven effective against this viral infectious disease.Drug development with conventional discovery pipelines will not meet the immediate needs.Therefore, effective prevention and treatment (drugs and vaccines) against the highly pathogenic coronaviruses is in urgent need.Identification of readily available drugs or natural products for repositioning in COVID-19 therapy avails a relatively rapid way to clinical treatment5,6.
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