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本文就尿毒症患者血小板功能障碍与血小板生成缺陷、血小板膜糖蛋白(GPIb)异常、vWF:Ag浓度及瑞斯托霉素辅因子活性改变以及血小板内在缺陷(贮存池和前列腺素分泌缺陷)的关系作了综述。同时对透析治疗、应用rhEpo、DDAVP及偶合雌激素改善尿毒症患者止血功能的价值作了概述。
In this review, we investigated the association between platelet dysfunction and platelet deformity, platelet glycoprotein (GPIb) abnormalities, vWF: Ag concentration, and ristocetin cofactor activity in patients with uremia, as well as intrinsic platelet defects (reservoir and prostaglandin secretion defects) The relationship was reviewed. At the same time, the value of dialysis treatment, application of rhEpo, DDAVP and conjugated estrogen to improve the hemostatic function of patients with uremia is summarized.