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应用银染技术对44例喉癌、7例喉乳头状瘤、8例喉正常粘膜的石蜡切片行核仁组成区相关嗜银蛋白(AsNOR)含量分析,结果表明:喉癌、喉乳头状瘤、喉正常粘膜之间AgNOR含量均有显著性差异;AgNOR含量与喉癌组织学分级、临床分期相关;分析有随访资料的30例喉癌患者AgNOR含量,发现术后3年内死亡的13例和仍存活的17例病人癌组织中AgNOR含量有极显著性差异。提示:AgNOR含量可作为喉良恶性肿瘤鉴别、喉癌分级、分期及预后估计的客观指标。
Application of silver staining on 44 cases of laryngeal cancer, 7 cases of laryngeal papilloma, 8 cases of laryngeal normal mucosa of paraffin sections of nucleolar organizer area related argyrophilic protein (AsNOR) content analysis showed that: laryngeal cancer, laryngeal papilloma , There was a significant difference in AgNOR content between normal laryngeal mucosa; AgNOR content was correlated with histological grade and clinical stage of laryngeal cancer; AgNOR content was analyzed in 30 laryngeal cancer patients with follow-up data and 13 patients were found to have died within 3 years after operation The remaining 17 cases of patients with AgNOR content in cancer tissue has a very significant difference. Tip: AgNOR content can be used as a differential diagnosis of laryngeal cancer, classification, staging and prognosis of laryngeal cancer objective indicators.