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全身放射治疗(TBI)是晚期癌症的姑息治疗手段。1905年Dessauer设计了三个X线管组成的全身照射装置。1923年Chauol及Lange首先报告TBI之12例何杰金病的治疗经验,此后该疗法在欧美不断使用,称为“Teschendorf”(欧洲)或“Heublein”(美洲)疗法。在40年代由于氮芥问世及TBI并发症等原因,此一疗法被弃置。50年代内脏移植兴起,TBI又被重视,以期获得免疫机制抑制之效,惟当时应用不多,疗效不著。60年以来由于不少晚期白血病及恶性淋巴瘤治疗取得成功,致使TBI应用日多,引人注目。
Whole body radiation therapy (TBI) is a palliative treatment for advanced cancer. In 1905 Dessauer designed a whole body irradiation device consisting of three X-ray tubes. In 1923, Chauol and Lange first reported the treatment experience of 12 cases of Hodgkin’s disease in TBI. Since then, the therapy has been continuously used in Europe and the United States and is called “Teschendorf” (Europe) or “Heublein” (Americas) therapy. In the 40’s due to the emergence of nitrogen mustard and TBI complications and other reasons, this therapy was abandoned. The rise of internal organs in the 1950s, TBI has also been valued in order to obtain the effect of inhibition of the immune system, but the application was not at that time, the efficacy can not be. Since the success of many advanced leukemia and malignant lymphoma treatments over the past 60 years, the use of TBI has attracted more attention.