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非何杰金氏淋巴瘤(NHL)的治疗效果迄今难使人满意,各种化疗方案能达到完全缓解者鲜有超过50%者。阿霉素对NHL 有很大疗效,故美国西南癌瘤协作组发起以阿霉素为主的化疗方案临床试用。合格患者随机纳入一组 CHOP 方案,即环磷酰胺(C)750毫克/平方米第一天,阿霉素(H)50毫克/平方米第一天,长春新碱(O)1.4毫克/平方米第一天,强地松(P)100毫克/日,第一至五天,如此每2～3周重复一次;另组 HOP 方案,即阿霉素50毫克/平方米第一天,长春新碱1.4毫克/平方米第一天,强地松100毫克/日第一至第五天,亦每2～3周重复一次。纳入 CHOP 可供分析的 NHL 患者204例,HOP 组有216例,皆为临床Ⅲ及Ⅳ期。完全缓解率在前组为71%,加上部
The therapeutic effect of non-Hodgkin’s lymphoma (NHL) has so far been difficult to satisfy, and less than 50% of complete remissions have been achieved with various chemotherapy regimens. Adriamycin has a great effect on NHL, so the Southwest United Cancer Group initiated a clinical trial of a chemotherapy regimen based on doxorubicin. Qualified patients were randomized to receive one CHOP regimen: cyclophosphamide (C) 750 mg/m2 on the first day, doxorubicin (H) 50 mg/m2 on the first day, and vincristine (O) 1.4 mg/sq. On the first day of rice, pine (P) 100 mg/day, first to five days, so repeated every 2 to 3 weeks; another group HOP program, that is, doxorubicin 50 mg/m2 on the first day, Changchun Sodium 1.5 mg/m2 for the first day, and 100 mg/day for the first five days of strong pine, repeated every 2 to 3 weeks. Twenty-four NHL patients were included in the CHOP analysis. There were 216 patients in the HOP group. All were clinical stages III and IV. The complete remission rate in the former group was 71%, plus