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腺苷脱氨酶(AD)是一种水解酶类,可使腺苷水解为次黄苷和氨。在人体内广泛分布,血清中含有少量.最近,对肝病病人,开展了血清AD的研究,发现在肝硬变患者中其活性升高。但是,关于它的临床意义不明了之处还多,升高的机理也不太清楚. 此次,我们测定了各种肝疾患的血清AD活性,探讨了与常规肝功能检查的相关关系。另外,因AD在脾及淋巴结内的活性也高,所以一并研究了其与脾肿大的关系。
Adenosine deaminase (AD) is a hydrolytic enzyme that hydrolyzes adenosine to inosine and ammonia. Widely distributed in the human body, the serum contains a small amount.Recently, patients with liver disease, serum AD carried out in patients with liver cirrhosis found that its activity increased. However, the clinical significance of it is unknown and the mechanism of its increase is unclear.This time, we measured serum AD activity in various liver diseases and explored the correlation with routine liver function tests. In addition, since AD is also highly active in the spleen and lymph nodes, the relationship with splenomegaly is also studied.