病人血浆中如果含遗传性胆碱酯酶变异体,用琥珀胆碱则可出现呼吸抑制延长,Hanel等证实人群中有2.8%能发现有非典型酶E_1~uE_1~a杂合子,而同源非典型胆碱酯酶表型E_1~aE_1~a约占1/2800.作者报告一例出生3周新生儿,因用了琥珀胆碱引起呼吸暂停时间过长,静注人体血浆胆碱酯酶治疗有效.此例男婴体重3980g,入院做幽门切开术.检查血细胞压积41%,电解质正常,术前一小时注阿托品0.1mg,静注硫贲妥钠5mg·kg~(-1),面罩吸氧,静注琥珀胆碱6mg后气管插管,吸入0.5%氟烷-N_2O-O_2(4:2)维持麻醉.输含5%葡萄糖的林格氏 If the patient’s plasma contains genetic variants of cholinesterase, succinylcholine respiratory depression can be prolonged, Hanel and other confirmed that 2.8% of the population can be found atypical enzymes E_1 uE_1 a heterozygote, and homologous Atypical cholinesterase phenotype E_1 ~ aE_1 ~ a accounted for about 1 / 2800. The authors report a newborn born 3 weeks, due to the use of succinylcholine caused by prolonged apnea, intravenous human plasma cholinesterase treatment Effective in this case the baby boy weighing 3980g, admission to do pyloric incision .Check the hematocrit 41%, normal electrolyte, preoperative an hour note atropine 0.1mg, intravenous injection of 5mg · kg -1, Mask oxygen inhalation, intravenous injection of succinylcholine 6mg intratracheal intubation, inhalation of 0.5% halothane - N_2O-O_2 (4: 2) to maintain anesthesia lose 5% glucose in Ringer’s