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甲氰咪胍是治疗胃及十二指肠溃疡的有效药物,一般认为其本身毒副作用少,使用安全.但近些年来发现,该药与某些药物配伍或在某些生理病理条件下应用,可造成许多不良后果,有时,可带来致命危害.现简单综述如下:一、对药物吸收的影响甲氰咪胍阻滞H_2受体,抑制胃酸分泌使胃内PH升高3—5,故对一些在较低PH下溶解的药物可减少其吸收.酮康唑(Ketoconzole)是新广谱抗真菌药,甲氰咪胍可使其溶解度降低,生物利用度下降65%,血浆药物峰浓度下降5倍.
Cimetidine is an effective drug for the treatment of stomach and duodenal ulcer, which is generally considered to be less toxic and safe to use, but in recent years it has been found that the drug is compatible with certain drugs or under certain physiological and pathological conditions , Can cause a lot of adverse consequences, and sometimes can be fatal. Now briefly summarized as follows: First, the impact of drug absorption Cimetidine block H_2 receptors, inhibition of gastric acid secretion so that the stomach increased PH 3-5, So some drugs that dissolve at lower pH can reduce their absorption.Ketoconzole is a new broad-spectrum antifungal agent, cimetidine can make it less soluble, bioavailability decreased by 65%, plasma drug peak Concentration decreased by 5 times.