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测定78例血清肌红蛋白(Mb)浓度,其中33例急性心肌梗塞(AMI)急性期入院,最早在起病后1.5小时升高,21例在冠脉再通治疗后(46.7±17.3)分钟出现升高的峰值,平均为(889.9±47.3)μg/L,比再灌注前升高65.5%,Mb异常升高持续(37.3±6.8)小时。另观察20例不稳定性心绞痛(UAP)患者,疼痛发作期和间歇期Mb分别为(56.3±21.6)μg/L和(41.6±2.3)μg/L。25例运动试验受试对象的结果:运动前后分别为(33.7±12.4)μg/L和(46.3±21.3)μg/L。该2组与AMI组入院Mb相比,差异均显著(P<0.05)。AMI患者Mb诊断的敏感度为100%,特异度为84%,阳性预测值为89.2%,阴性预测值为100%。本研究表明,Mb是AMI急性期诊断很敏感且较特异性的生化指标,有助于与UAP相鉴别。
Determination of 78 cases of serum myoglobin (Mb) concentrations, of which 33 cases of acute myocardial infarction (AMI) acute admission, the earliest onset 1.5 hours after the rise, 21 cases of coronary recanalization treatment (46.7 ± 17.3) minutes, with an average of (889.9 ± 47.3) μg / L, an increase of 65.5% compared with that before reperfusion and an abnormal increase of Mb (37.3 ± 6). 8) hours. In addition, 20 patients with unstable angina pectoris (UAP) were observed. The Mb of Mb was (56.3 ± 21.6) μg / L and (41.6 ± 2.3) μg / L, respectively. The results of 25 exercise test subjects were (33.7 ± 12.4) μg / L and (46.3 ± 21.3) μg / L before and after exercise, respectively. There was significant difference (P <0.05) between the two groups and the AMI group admission Mb. AMI patients had a sensitivity of 100% for Mb diagnosis, a specificity of 84%, a positive predictive value of 89.2%, and a negative predictive value of 100%. This study shows that, Mb is a sensitive and specific biochemical indicator of AMI acute phase diagnosis, help to differentiate and UAP.