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目的 探讨 2 型糖尿病与超敏 C 反应蛋白(Hs CRP)水平的关系。方法 采用病例对照研究方法。选取对照(NGT)组、糖耐量降低(IGT)组、2型糖尿病(DM)组各60例(男、女各30例且年龄相当)。计算体重指数(BMI),做口服75g葡萄糖耐量试验(OGTT)并测定空腹胰岛素(FINS)、Hs CRP及血脂水平。结果 病例组(IGT组和DM组)较对照组(NGT)Hs CRP显著升高(P<0.05),且与FPG、TC呈显著正相关,与 HDL呈显著负相关。多元逐步回归分析显示 BMI、FPG、HOMA IR、TC和Lp(a)是影响Hs CRP水平的主要因素。结论 IGT和DM患者血清中Hs CRP显著高于NGT组,Hs CRP对预测 DM患者发生动脉粥样硬化有一定价值。
Objective To investigate the relationship between type 2 diabetes and high-sensitivity C-reactive protein (Hs CRP). Methods A case-control study was used. The control group (NGT), IGT group, and type 2 diabetes group (60 cases each), 30 males and 30 females with the same age, were selected. Body mass index (BMI) was calculated and oral 75g glucose tolerance test (OGTT) was performed and fasting insulin (FINS), Hs CRP and blood lipid levels were measured. Results Hs CRP in IGT group and DM group was significantly higher than that in NGT group (P <0.05), and was positively correlated with FPG and TC, but negatively correlated with HDL. Multivariate stepwise regression analysis showed that BMI, FPG, HOMA IR, TC and Lp (a) were the main factors affecting the level of Hs CRP. Conclusion The serum levels of Hs-CRP in patients with IGT and DM are significantly higher than those in NGT patients. Hs-CRP is of value in predicting atherosclerosis in DM patients.