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1965年,Paronetto应用免疫细胞化学方法证实在恶性高血压者纤维样坏死的小动脉壁上有γ-球蛋白和补体存在,认为高血压过程中可能有免疫因素参与,以后Suendssen发现在各种实验性高血压动物模型中高血压的维持和血管损害依赖于正常的胸腺功能,从而引起人们对免疫与高血压之间关系的浓厚兴趣与重视。1970年,Ebringer首次报导严重高血压者有血清免疫球蛋白(Ig)改变,IgG明显升高,对这种现象和它的临床意义,近年来文献中陆续有研究与探讨,
In 1965, Paronetto used immunocytochemistry to confirm the presence of gamma-globulin and complement on the arteriolar wall of patients with fibrotic necrosis in patients with malignant hypertension. He thought there might be immune factors involved in the process of hypertension. Afterwards, Suendssen found that in various experiments Hypertension in animal models of hypertension maintenance and vascular damage depends on the normal thymus, which led to the relationship between the immune and high blood pressure of great interest and attention. In 1970, Ebringer first reported severe immunoglobulin (Ig) changes in patients with high blood pressure, IgG was significantly increased, this phenomenon and its clinical significance in the literature in recent years have been studied and discussed,