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目的:分析不同配伍配比对黄连-大黄药对中小檗碱溶出影响,优化黄连-大黄药的配比方法。方法:4种配伍方式,每种配伍方式3个配伍比例的样品相应处理后,采用RP-HPLC检测各供试品的小檗碱含量。结果:在试验考察的配伍范围内,分煎合并各组小檗碱的溶出均高于合煎组;分煎后合并的药液经离心处理后小檗碱含量降低;大黄液中加入明胶处理后再与黄连液混合,混合液中小檗碱含量提高。结论:大黄-黄连药对分煎后混合更有利于药液中小檗碱的保留。
OBJECTIVE: To analyze the effect of different compatibility ratio on the dissolution of berberine in Coptis chinensis-Rhubarb and to optimize the method of rhizoma coptidis-Rhubarb. Methods: Four kinds of compatibility methods and three compatibility methods for each compatibility method were applied to detect the content of berberine in each sample by RP-HPLC. Results: Within the compatibility range of the experimental study, the dissolution of berberine in each group was higher than that in the combined group. The content of berberine in the combined liquid after the decoction was reduced by centrifugation. The gelatin treatment And then mixed with Coptis, the mixture of berberine content increased. Conclusion: Rhubarb - Coptis on the decoction after mixing more conducive to the retention of berberine solution.