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目的建立中国5~14岁儿童呼气峰值流速(PEFR)正常值范围和预测值方程式。方法根据中国地理分布选取5个研究中心:华南(广州)、华东(苏州)、西南(成都)、西北(西安)、华北(北京),随机抽取2010年10月~12月就读于各研究中心的学生发放问卷和知情同意书。其中问卷填写正确、家长签署知情同意书、年龄在5~14岁、无任何心肺及其他系统疾病史、近4周无呼吸道疾病史,当面询问和体格检查呼吸、心率、胸廓、肺部体及身高、体质量均在正常范围者作为研究对象。本研究经医院伦理委员会同意并备案。采用英国制造的Vitrograph简易峰流速仪,于上午8:00-12:00采取坐姿行峰流速测定6次,记录3次最好值。以实测指标采用SPSS 20.0统计软件,经多元逐步回归和多元线性回归,得出预测值方程式。结果共纳入符合研究对象标准的儿童3169名,男1596名、女1573名;其中各中心的纳入研究对象、男、女人数分别为:北京(365,184,181)、成都(423,201,222)、苏州(1046,517,526)、西安(942,481,461)广州(396,213,183),每个年龄段人数均等。PEFR值随着年龄的增长,统计有差异,P<0.001;男孩比女孩高,其中5岁,10岁,11岁组的男女性简易PEF值差别没有统计学意义,其他年龄段差别均有统计学意义,(P<0.05)。PEFR与年龄、身高、体重、BMI都具有相关性,其中PEF值与身高的相关性最强。结论本研究建立了中国5~14岁儿童呼气峰值流速(PEFR)正常值范围和预测值方程式。PEFR值随年龄增高而增高,其受儿童身高影响超过体质量和年龄变化。
Objective To establish the normal range and prediction equation of peak expiratory flow (PEFR) in Chinese children aged 5-14 years. Methods According to the geographical distribution in China, five research centers were chosen: South China (Guangzhou), East China (Suzhou), Southwest (Chengdu), Northwest (Xi’an) and North China (Beijing) Of students issued questionnaires and informed consent forms. The questionnaire was filled in correctly and the parents signed the informed consent form. The patients were aged 5-14 years old without any history of cardiopulmonary and other systemic diseases. They had no history of respiratory diseases in the past 4 weeks. They interviewed and examined the respiration, heart rate, thorax, lungs, Height, body mass are in the normal range as the research object. This study was approved by the hospital ethics committee and filed. The British-made Vitrograph simple peak velocity meter, 8:00 am to 12:00 sitting posture peak-flow velocity measured 6 times, record 3 times the best value. The SPSS 20.0 statistical software was used to measure the index, and the predictive value equation was obtained through multiple stepwise regression and multiple linear regression. Results A total of 3169 children, 1596 males and 1573 females, were enrolled in the study. Among them, the number of males and females included in the study was Beijing (365,184,181), Chengdu (423,201,222), Suzhou (1046,517,526) ), Xi’an (942,481,461) Guangzhou (396,213,183), equal in each age group. PEFR value with age, the statistics were different, P <0.001; boys were higher than girls, including 5-year-old, 10-year-old group, 11-year-old group of simple PEF values for men and women was not statistically significant, Significance of learning (P <0.05). PEFR and age, height, weight, BMI are related, which PEF value and the height of the strongest correlation. Conclusions This study established a normal range and predicted value equation of peak expiratory flow (PEFR) in Chinese children aged 5-14 years. PEFR values increased with age, which were influenced by the height of the child over body weight and age.