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MicroRNA(miRNA)是一种高保守,长度大概21-23个核苷酸,非蛋白编码RNA,起着调节基因表达的作用。近年来有关miRNA与肺癌的关系已经得到证实,并且成为当前研究的热点。miRNA能整体调节基因表达,这使得miRNA表达谱在作为生物信号方面比蛋白编码基因更具有提示作用。最近发现miRNA以被保护的状态存在于循环血液中,这使得miRNA表达的发现具有非侵袭性、重现性以及易检测性。研究显示血浆miRNA表达谱可作为肺癌生物信号分子,在肺癌早期诊断、判断预后和指导化疗药物应用等方面具有重要作用。本文将对血浆miRNA与肺癌的研究进展,以及在肺癌早期诊断、判断预后和指导化疗药物应用等方面作一综述。
MicroRNA (miRNA) is a highly conserved, approximately 21-23 nucleotide, non-protein-coding RNA that plays a role in regulating gene expression. In recent years, the relationship between miRNA and lung cancer has been confirmed, and has become the current research hot spots. miRNAs can regulate gene expression as a whole, which makes miRNA expression more cue than protein-coding genes as biological signals. Recently, miRNAs were found in circulating blood in a protected state, making the discovery of miRNA expression noninvasive, reproducible, and easily detectable. Studies have shown that plasma miRNA expression profile can be used as lung cancer bio-signal molecules, plays an important role in the early diagnosis of lung cancer, prognosis and guide the application of chemotherapy drugs. This article will review the progress of plasma miRNA and lung cancer, as well as in the early diagnosis of lung cancer, prognosis and guide the application of chemotherapy drugs and so on.