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目的探讨幽门螺杆菌(HP)感染的慢性糜烂性胃炎合并缺铁性贫血(IDA)患者最佳的补铁时机。方法选择HP感染的慢性糜烂性胃炎合并IDA患者68例,随机分为治疗组36例和对照组32例,治疗组在根除HP方案(2周)结束时服多糖铁胶囊(0.15/d)治疗,对照组在开始根除HP方案时就补铁。8周后观察贫血改善(主要观察血红蛋白回升)及上腹不适症状缓解情况。结果两组患者贫血均明显改善,治疗组略逊于对照组,但差异无统计学意义(P>0.05);然而上腹不适症状的缓解治疗组较对照组快(P<0.05)。结论 HP感染的慢性糜烂性胃炎合并IDA患者补铁宜选择在根除HP后进行。
Objective To investigate the optimal timing of iron supplement in patients with chronic erosive gastritis infected with Helicobacter pylori (HPA) and with iron deficiency anemia (IDA). Methods Sixty-eight patients with HP-infected chronic erosive gastritis complicated with IDA were randomly divided into treatment group (36 cases) and control group (32 cases). The treatment group was given polysaccharide iron capsule (0.15 / d) In the control group, iron supplementation was initiated at the beginning of the HP program of eradication. After 8 weeks to observe the improvement of anemia (mainly observed hemoglobin rise) and the symptoms of upper abdominal discomfort. Results The anemia was significantly improved in both groups. The treatment group was slightly lower than the control group, but the difference was not statistically significant (P> 0.05). However, the treatment group with upper abdominal discomfort was faster than the control group (P <0.05). Conclusion Hepatitis E infection of chronic erosive gastritis with IDA patients should be selected iron supplementation after eradication of HP.