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作者采用免疫羧化胶乳法和一组抗人大肠癌相关抗原的单克隆抗体,对554例人粪便中一组大肠癌相关抗原进行测定。结果表明:28例大肠癌,其阳性率为92.9%,特异性为100.0%,正确指数为92.8%;5例绒毛管状腺瘤均为阳性;4例管状腺瘤息肉阳性率为50.0%;11例炎性息肉阳性率为18.2%;结肠炎、上消化道良性疾病、上消化道恶性肿瘤、正常人则均为阴性。研究提示:免疫羧化胶乳法检测粪便中一组大肠癌相关抗原敏感性好,特异性高。免疫胶乳法作为定性试验,不需要特殊仪器,操作简便,快速,便于掌握推广,适用于群体大肠癌普查。
The authors used the immunocarboxylated latex method and a panel of monoclonal antibodies against colorectal cancer-associated antigens to determine a group of colorectal cancer-associated antigens in 554 human feces samples. The results showed that: 28 cases of colorectal cancer, the positive rate was 92.9%, the specificity was 100.0%, the correct index was 92.8%; 5 cases of villous tubular adenoma were positive; 4 cases of tubular adenomatous polyp positive The rate was 50.0%; the positive rate of 11 cases of inflammatory polyps was 18.2%; colitis, benign diseases of the upper gastrointestinal tract, upper gastrointestinal cancer, and normal persons were all negative. The research suggests that the immunocarboxylated latex method has a good sensitivity and specificity in detecting a group of colorectal cancer-associated antigens in feces. As a qualitative test, the immune latex method does not require special instruments. It is easy to operate, fast, and easy to grasp and popularize. It is suitable for colon cancer screening.