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测定了ｄ－α－生育酚（ｄ－α－Ｔ）和ｄ－α－生育酚乙酸酯（ｄ－α－ＴＡ），ｄ－α－生育酚烟酸酯（ｄ－α－ＴＮ），ｄ－α－生育酚丁二酸酯（ｄ－α－ＴＳ）等生育酚酯（ｄ－α－ＴＥ）单分子膜，及ｄ－α－Ｔ，ｄ－α－ＴＥ与二棕榈酰基磷脂酰胆碱（ＤＰＰＣ），二油酰基磷脂酰胆碱（ＤＯＰＣ）混合单分子膜的表面压－平均分子面积等温线。结果表明：零表面压下，ｄ－α－ＴＥ单分子膜的平均分子面积大于ｄ－α－Ｔ单分子膜的平均分子面积，且不随酯基而改变；ｄ－α－ＴＥ使ＤＰＰＣ单分子膜的崩裂压降低，但不改变ＤＯＰＣ单分子膜的崩裂压，ｄ－α－ＴＥ引起ＤＰＰＣ单分子膜的膨胀和ＤＯＰＣ单分子膜的凝缩，膨胀或凝缩的程度基本上不随ｄ－α－ＴＥ而改变；ｄ－α－ＴＡ／ＤＯＰＣ单分子膜的性质与ｄ－α－Ｔ／ＤＯＰＣ单分子膜类似，与ｄ－α－ＴＡ／ＤＰＰＣ单分子膜明显不同，表明在生育酚及其酯与磷脂酰胆碱的混合膜中，分子之间疏水部分的相互作用更显著地影响膜性质。
The d-α-tocopherol acetate (d-α-T), d-α-tocopherol acetate (d-α-TE) monolayers such as d-α-tocopherol succinate (d-α-TS) and d-palmitoyl phosphatidyl The surface pressure-average molecular area isotherms of choline (DPPC), dioleoylphosphatidylcholine (DOPC) mixed monolayers were investigated. The results show that the average molecular area of d-α-TE monolayer is greater than the average molecular area of d-α-T monolayer at zero surface pressure and does not change with the ester group. D-α-TE makes DPPC single molecule The collapse pressure of the film is low, but does not change the collapse pressure of the DOPC monolayer. The degree of d-α-TE induced dilation of the DPPC monolayer and the condensation, expansion or condensation of the DOPC monolayer is not substantially dependent on the d-α -TE. The properties of d-α-TA / DOPC monolayer are similar to that of d-α-T / DOPC monolayer and are obviously different from that of d-α-TA / DPPC monolayer. In a mixed membrane of ester and phosphatidylcholine, the interaction of the hydrophobic moieties between molecules affects the membrane properties more significantly.