肠内营养(EN)具有符合生理、并发症少、价格低等优势,成为临床上存在营养不良或营养风险病人首选的营养支持方式。但在危重症病人中,常需通过饲管接受口服制剂和药物的治疗,而经饲管给药由于物理、药理、药剂等因素常导致不良事件的发生,如饲管堵塞、药物毒性、胃肠道刺激作用增强、药动学或药效学改变等[1],影响病人的临床结局。以下我们对EN支持期间管饲药物的相关注意事项进行探讨。1经EN管给药致不良事件的主要因素分析 Enteral nutrition (EN) with physiological, less complications, low prices, as the clinical presence of malnutrition or nutritional risk of patients preferred nutritional support. However, in critically ill patients, oral administration and drug treatment are often required through feeding tubes. Administration through feeding tubes often leads to adverse events such as obstruction of the feeding tube, toxicity of drugs, stomach Intestinal irritation increased, pharmacokinetic or pharmacodynamic changes [1], affecting the patient’s clinical outcome. In the following we discuss the related notes on tube feeding during EN support. 1 EN tube administration of adverse events caused by the analysis of the main factors